Orthopaedics: gene therapy's dark horse

The Horse Gene Map.

The first contribution to the horse gene map was identification of linkage between 6-phosphogluconate dehydrogenase and the K blood group system (Sandberg 1974). During the next 20 years, additional linkage groups were identified and the map was periodically reviewed (Sandberg and Andersson 1993). Gene mapping discoveries were incidental to studies of new genetic systems for parentage analyses ...

Black Carbon: The Dark Horse of Climate Change Drivers

A 172 Black Carbon The Dark Horse of Climate Change Drivers For decades, efforts to slow global warming have mostly aimed to limit heat-trapping emissions of carbon dioxide (CO2). Now scientists are pointing to a different class of warming agents they say also must be targeted to keep global temperatures in check. Dubbed “shortlived climate forcings” (SLCFs), these other emissions— namely, blac...

Prolongations: A dark horse in the disfluency stable

This paper studies a specific type of disfluency, viz. segment prolongation (PR), i.e., the “stretching out” of speech sounds as a means of hesitation. It is shown that the occurrence of PRs varies as a function of phone type, position in the word, lexical factors and word class, and that PRs are subject to phonotactic constraints in Swedish. A comparison between Swedish and Tok Pisin suggests ...

An intestinal Trojan horse for gene delivery.

The intestinal epithelium forms an essential element of the mucosal barrier and plays a critical role in the pathophysiological response to different enteric disorders and diseases. As a major enteric dysfunction of the intestinal tract, inflammatory bowel disease is a genetic disease which results from the inappropriate and exaggerated mucosal immune response to the normal constituents in the ...

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